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Invitrogen
Human PHAP Synthetic Peptide
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Product Details
PEP-0143
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to amino acids near the amino terminus of human PHAP.
PEP-0143 can be used as a blocking peptide with polyclonal antibody PA5-20024.
Target Information
Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; acidic (leucine-rich) nuclear phosphoprotein 32 family, member E; acidic nuclear phosphoprotein pp32; acidic protein rich in leucines; cerebellar leucine rich acidic nuclear protein; epididymis secretory sperm binding protein; hepatopoietin Cn; I1PP-2A; inhibitor-1 of protein phosphatase-2A; LANP-L; LANP-like protein; leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein like; mapmodulin; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; putative HLA-DR-associated protein I; putative HLA-DR-associated protein I-2; putative human HLA class II associated protein I; silver-stainable protein SSP29; unnamed protein product
Gene Aliases: APRIL; C15orf1; HPPCn; I1PP2A; LANP; LANP-L; LANPL; MAPM; PHAP1; PHAPI; PHAPI2; PP32; SSP29
UniProt ID: (Human) P39687, (Human) Q92688, (Human) Q9BTT0
Entrez Gene ID: (Human) 8125, (Human) 10541, (Human) 81611
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