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Invitrogen
Human PUMA Synthetic Peptide
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Product Details
PEP-0127
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 14 amino acids near the carboxy terminus of human PUMA.
PEP-0127 can be used as a blocking peptide with polyclonal antibody PA5-20007.
Target Information
PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; FLJ42994; JFY-1; p53 up-regulated modulator of apoptosis; p53-induced BH3-only protein; p53-upregulated modulator of apoptosis; unnamed protein product
Gene Aliases: BBC3; JFY-1; JFY1; PUMA
UniProt ID: (Human) Q96PG8
Entrez Gene ID: (Human) 27113
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