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Invitrogen
Human RARA, Ligand Binding Domain, GST Tag Recombinant Protein
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Product Details
PV4415
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
176-462
Tag
GST-tag
Class
Recombinant
Type
Protein
Purity
95% by SDS-PAGE
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
proprietary buffer
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
Retinoic acid receptor alpha, ligand binding domain (RARA-LBD) is a 59.53 kDa recombinant human protein (amino acids 176-462) expressed as a GST-tagged fusion protein in baculovirus-infected insect cells. RARA-LBD is expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator recruitment studies.
Protein Form: Recombinant, Ligand Binding Domain
Target Information
RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: nuclear receptor; Nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR Alpha; RAR-alpha; RARA; retinoic acid; retinoic acid receptor; Retinoic acid receptor alpha; retinoic acid receptor, alpha polypeptide; RRA; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product
Gene Aliases: NR1B1; RAR; RARA; RARalpha
UniProt ID: (Human) P10276
Entrez Gene ID: (Human) 5914
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