Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Highest antigen sequence indentity to the following orthologs: Mouse (82%), Rat (82%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57248. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The Ras-related low molecular mass GTPases participate in signal transduction involving a variety of cellular functions, including cell-cycle progression, cellular differentiation, cytoskeletal organization, protein transport and secretion. The Ras-GTPase-activating protein (RASGAP) forms a complex with a second protein, p190, in growth factor stimulated and tyrosinekinase transformed cells. The RASGAP p190 complex may serve to couple Ras- and Rho-mediated signaling pathways. RASGAP forms an abundant SH2-mediated complex with p190 RhoGAP in cells expressing activated tyrosine kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CM-AVM; CMAVM; DKFZp434N071; GAP1m; GTPase-activating protein 1m; GTPase-activating protein of RAS; p120RASGAP; PKWS; Ras GTPase-activating protein 2; RASA
Gene Aliases: GAP1M; RASA2; RASGAP
UniProt ID: (Human) Q15283
Entrez Gene ID: (Human) 5922
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support