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Invitrogen
Human RIT2 (aa 177-213) Control Fragment Recombinant Protein
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Product Details
RP-110063
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LVREIRKKESMPSLMEKKLKRKDSLWKKLKGSLKKKR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (84%), Rat (84%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-145029. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Ras-like without CAAX 2 (RIT2) is a gene located on chromosome 18q12.1, encoding a member of the Ras superfamily of small GTPases. RIT2 is primarily expressed in neuronal tissues, where it plays a crucial role in intracellular signaling pathways that regulate neuronal differentiation, survival, and plasticity. Functionally, RIT2 is involved in neurotrophic factor signaling, contributing to the maintenance and function of the nervous system. This protein interacts with various downstream effectors to influence cellular processes such as growth factor response and neuronal signaling dynamics. Alterations or mutations in RIT2 have been associated with neurological disorders, including Parkinson's disease, implicating its role in neurodegenerative processes. Research into RIT2 aims to elucidate its precise mechanisms in neural signaling and its potential as a therapeutic target for treating neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTP-binding protein Rit2; GTP-binding protein Roc2; Ras-like protein expressed in neurons; Ras-like without CAAX 2; Ras-like without CAAX protein 2; Ric-like, expressed in neurons
Gene Aliases: RIBA; RIN; RIT2; ROC2
UniProt ID: (Human) Q99578
Entrez Gene ID: (Human) 6014
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