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Invitrogen
Human SIGLEC5 Control Fragment Recombinant Protein
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Product Details
RP-90058
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
KARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSAGDQASPPGDAPPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (28%), Rat (28%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82378. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
SIGLEC5 (CD170) is a member of the sialic acid-binding immunoglobulin-like lectin family expressed mainly on myeloid cells such as neutrophils and monocytes. It functions as an inhibitory receptor that recognizes sialylated glycans and transduces signals through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail, helping regulate innate immune responses and dampen inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD170; CD33 antigen-like 2; OB-binding protein 2; OB-BP2; Obesity-binding protein 2; Sialic acid-binding Ig-like lectin 5; sialic acid-binding immunoglobulin-like lectin 5; Siglec-5
Gene Aliases: CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5; SIGLEC5
UniProt ID: (Human) O15389
Entrez Gene ID: (Human) 8778
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