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Invitrogen
Human SPRED1 Synthetic Peptide
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Product Details
PEP-0737
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 20 amino acids near the center of human Spred1.
PEP-0737 can be used as a blocking peptide with polyclonal antibody PA5-20617.
Target Information
The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes; it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EVH1/Sprouty domain containing protein; protein phosphatase 1, regulatory subunit 147; Spred-1; Sprouty-related, EVH1 domain-containing protein 1; suppressor of Ras/MAPK activation; unnamed protein product
Gene Aliases: hSpred1; LGSS; NFLS; PPP1R147; spred-1; SPRED1
UniProt ID: (Human) Q7Z699
Entrez Gene ID: (Human) 161742
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