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Highest antigen sequence indentity to the following orthologs: Mouse (71%), Rat (71%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-84126. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
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Protein Aliases: MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP-1; OPA-interacting protein 1; tcag7.1300; thyroid hormone receptor interacting protein 6; Thyroid receptor-interacting protein 6; TR-interacting protein 6; ZRP-1; zyxin related protein 1; Zyxin-related protein 1
Gene Aliases: OIP-1; OIP1; TRIP-6; TRIP6; TRIP6i2; ZRP-1
UniProt ID: (Human) Q15654
Entrez Gene ID: (Human) 7205
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