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Invitrogen
Human ZBTB2 Synthetic Peptide
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Product Details
PEP-0779
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 14 amino acids near the center of human ZBTB2.
PEP-0779 can be used as a blocking peptide with polyclonal antibody PA5-20659.
Target Information
ZBTB2 is a transcription factor gene that belongs to the BTB/POZ zinc-finger family, characterized by a BTB/POZ domain at the N-terminus and multiple zinc-finger domains at the C-terminus. This gene is known for its role in regulating gene expression, particularly in the repression of genes like ARF, p53, and p21, and it functions as both a repressor and activator. ZBTB2 interacts with a variety of proteins involved in complex biological processes such as RNA processing, transcription regulation, and DNA packaging. Its zinc-finger domains predominantly belong to C2H2 and PHD types. ZBTB2 is involved in nucleosome remodeling through its interaction with chromatin modifiers and histone chaperones during developmental cell state transitions. The gene has been implicated in human cancers, where it functions as an oncogene, particularly in gastric cancers, and plays a role in the development of chronic myeloid leukemia. ZBTB2's localization at promoter regions is noted for colocalizing with several other chromatin-modifying proteins like EP400, KAT5, MBD3, and CHD4, indicating its significant role in chromatin dynamics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: unnamed protein product; Zinc finger and BTB domain-containing protein 2; ZNF909
Gene Aliases: KIAA1483; ZBTB2; ZNF437
UniProt ID: (Human) Q8N680
Entrez Gene ID: (Human) 57621
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