Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recombinant Murine Artemin is a disulfide-linked homodimer formed by two identical 113 amino acid subunits with a calculated molecular weight of 24.2 kDa.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Artemin
Gene Aliases: Artn; neublastin
UniProt ID: (Mouse) Q9Z0L2
Entrez Gene ID: (Mouse) 11876
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