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Invitrogen
Mouse DIABLO Synthetic Peptide
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Product Details
PEP-0100
Product Specifications
Species Reactivity
Mouse
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of mouse Smac.
PEP-0100 can be used as a blocking peptide with polyclonal antibody PA5-19975.
Target Information
DIABLO (smac), a mitochondrial protein, activates various forms of apoptosis. This activation may be due to the neutralization of one or more members of the IAP family of apoptosis inhibitory proteins. Smac exits the mitochondria and enter the cytosol during certain apoptosis triggered events. Mitochondrial-mediated apoptosis is important in animal development and tissue homeostasis, with alterations resulting in a range of malignant disorders. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol. The release of these proteins, however, occurs via different mechanisms. Smac/DIABLO has also been found to play a key role in regulating the sensitization of cancer cells to apoptosis (both immune and drug-induced).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Diablo homolog, mitochondrial; Diablo IAP-binding mitochondrial protein; DIABLO-S; direct IAP binding protein with low PI; Direct IAP-binding protein with low pI; FLJ10537; FLJ25049; hCG_1782202; Second mitochondria-derived activator of caspase; Smac; Smac protein; SMAC3
Gene Aliases: 0610041G12Rik; 1700006L01Rik; AU040403; Diablo; Smac
UniProt ID: (Mouse) Q9JIQ3
Entrez Gene ID: (Mouse) 66593
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