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Invitrogen
Mouse DNMT3B (aa 1-14) Synthetic Peptide
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Product Details
PEP-117
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
50 µg
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
PEP-117 is two 14 amino acid synthetic peptides whose sequences are derived from amino acids 1-14 of mouse Dnmt3b protein with a carboxy-terminal cysteine added for carrier protein conjugation. The sequence of this peptide is (amino to carboxy terminus): M (1)-K-G-D-S-R-H-L-N-E-E-E-G-A (14)-C
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse Dnmt3b, catalog # PA1-884. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
Target Information
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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