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PEP-233 is a 17 amino acid synthetic peptide corresponding to amino acid residues 348-364 from mouse lysophosphatidic Acid Receptor 1. The sequence of this peptide is (amino to carboxy terminus): L N H T I L A G V H S N D H S V V.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, catalog # PA1-1041. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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