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Invitrogen
Mouse IFN-alpha A Recombinant Protein
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Product Details
121001
Applications
Tested Dilution
Publications
Product Specifications
Species
Mouse
Expression System
E. coli
Molecular weight
19.3 kDa
Class
Recombinant
Type
Protein
Purity
>95%
Endotoxin concentration
<1 EU/µg
Activity
EC50 ~ 5 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394] with the exception that EMCV rather than VSV was used as the challenge. The activity was determined relative to a lab standard of Mu IFN-alpha-A which was calibrated to the NIH mouse IFN-alpha- standard (Ga02-901-511).
Conjugate
Form
Liquid
Concentration
Lot-specific
Purification
purified
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
Store at -70°C or below for retention of full activity. Thaw product vial by incubation in cold tap water until just thawed. Aliquot and refreeze unused contents to minimize effects of freeze thawing. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of product should be in buffers containing protein such as 0.1% BSA or tissue culture media with serum. Dilution for freezing of material below 2 x 10^5 units/mL is not recommended. One freeze thaw cycle is equivalent to thawing an aliquot prepared from the material received.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha-1; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); Interferon alpha-1; Interferon alpha-1/13 (IFN-alpha-1/13); interferon alpha-2; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); MGC138207; MGC138505; MGC138507; novel interferon alpha (Ifna) family member
Gene Aliases: Gm12597; Ifa1; Ifa2; Ifna1; Ifnaa; MuIFN-alpha-A; OTTMUSG00000007655
UniProt ID: (Mouse) P01572
Entrez Gene ID: (Mouse) 15962, (Mouse) 242517, (Mouse) 15965
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