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Invitrogen
Mouse SIGIRR Synthetic Peptide
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Product Details
PEP-0196
Product Specifications
Species Reactivity
Mouse
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of mouse SIGIRR.
PEP-0196 can be used as a blocking peptide with polyclonal antibody PA5-20078.
Target Information
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC110992; single Ig IL-1 receptor related protein; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8
Gene Aliases: AI256711; Sigirr; TIR8
UniProt ID: (Mouse) Q9JLZ8
Entrez Gene ID: (Mouse) 24058
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