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Invitrogen
Rat IFN-beta Recombinant Protein
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Product Details
134001
Product Specifications
Species
Mouse,
Rat
Expression System
CHO cells
Molecular weight
19.68 kDa
Class
Recombinant
Type
Protein
Purity
>95%
Endotoxin concentration
<1 EU/µg
Activity
EC50 ~ 1 U/mL; determined by use of the cytopathic effect inhibition assay described in [Rubinstein, S. et al. (1981). J. Virol. 37, 755-758]; [Familletti, P.C. et al. (1981). Methods in Enzymology, Vol. 78, 387-394]As there is no international Rat IFN-alpha standard, units are determined with respect to the international reference standard for mouse interferon alpha/beta (mouse IFN-alpha/beta) provided by the National Institutes of Health.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Purification
purified
Storage buffer
PBS with 0.125M trehalose
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
After receipt, this product should be kept at -20°C while lyophilized and at -70°C after reconstitution in sterile distilled water for retention of full activity. After reconstitution, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. After thawing, this product is stable for at least four weeks at 4°C. Further dilute only in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Target Information
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IFN b; IFN β; IFN-beta; IFNbeta; IFNβ; Interferon; interferon 1da1; Interferon b; interferon beta 1, fibroblast; RP11-113D19.1
Gene Aliases: If1da1; Ifb; IFN-beta; IFNB
UniProt ID: (Mouse) P01575, (Rat) P70499
Entrez Gene ID: (Mouse) 15977, (Rat) 24481
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