DAP3 Proteins

Protein Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.

Synonyms

28S ribosomal protein S29, mitochondrial; 4921514D13Rik; bMRP-10; DAP3; DAP-3; death associated protein 3; death-associated protein 3; DKFZp686G12159; Ionizing radiation resistance conferring protein; MGC126058; MGC126059; mitochondrial 28S ribosomal protein S29; Mitochondrial small ribosomal subunit protein mS29; MRPS29; MRP-S29; S29mt