F1A alpha Proteins

Protein Information

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aalpha and FEM1-b. F1Aalpha/FEM1-b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aalpha is cleaved by CED-3 and caspase. FEM-1/F1Aalpha associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1Aalpha induces apoptosis. F1Aalpha is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aalpha is expressed in a variety of human and mouse tissues.

Synonyms

DKFZp451E0710; F1aa; F1A-alpha; fem-1 homolog B; fem-1 homolog b (C. elegans); Fem1b; FEM1-beta; FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; Fem-1-like in apoptotic pathway protein alpha; feminization 1 homolog b; feminization 1 homolog b (C. elegans); FIAA; Kiaa0396; mKIAA0396; mt-Fem; Protein fem-1 homolog B