FICD Proteins

Protein Information

Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context. The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it. In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity. Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083). [UniProt]

Synonyms

adenosine monophosphate-protein transferase FICD; AMPylator FICD; D5Ertd40e; De-AMPylase FICD; FIC domain containing; FIC domain protein adenylyltransferase; FIC domain-containing protein; fic S-phase protein cell division homolog; FICD; HIP13; HIP-13; huntingtin interacting protein 13; huntingtin interacting protein E; huntingtin interactor protein E; huntingtin yeast partner E; Huntingtin-interacting protein 13; huntingtin-interacting protein E; Hype; MGC5623; Protein adenylyltransferase FICD; protein adenylyltransferase FICD; adenosine monophosphate-protein transferase FICD; UNQ3041; UNQ3041/PRO9857