FTSJD2 Proteins

Protein Information

S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. [UniProt]

Synonyms

1300018I05Rik; AI451264; Cap methyltransferase 1; Cap1 2'O-ribose methyltransferase 1; cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; cmtr1; FtsJ methyltransferase domain containing 2; ftsJ methyltransferase domain-containing protein 2; ftsjd2; hMTr1; hypothetical protein LOC393102; interferon-stimulated gene 95 kDa protein; ISG95; KIAA0082; LOW QUALITY PROTEIN: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; LRRG00129; mKIAA0082; MTr1; RGD1307801; S-adenosyl-L-methionine-dependent methyltransferase ftsjd2; zgc:55336