KRT84 Proteins

Protein Information

The Keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair Keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair Keratins are responsible for creating nails and hair. There are two types of Keratins: the acidic class I Keratin proteins and the basic/neutral class II Keratin proteins. Keratin 84, also known as KRT84, HB4 or KRTHB4, is a 600 amino acid protein that is expressed in hair follicles. Keratin 84 is a basic/neutral type II Keratin protein which heterodimerizes with type I Keratins to create hair and nails. The gene encoding Keratin 84 maps to human chromosome 12 which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis and Kniest dysplasia.

Synonyms

65 kDa type II keratin; AV235125; hard keratin, type II, 4; HB4; HRb-1; K84; Kb24; keratin 84; keratin 84, type II; keratin complex 2, basic, gene 16; keratin complex 2, gene 16; keratin, hair, basic, 4; keratin, type II cuticular Hb4; Keratin-84; Krt2-16; Krt2-3; Krt84; KRTHB4; type II hair keratin 4; type II hair keratin Hb4; type II keratin Kb24; type-II keratin Kb24