MORF4 Proteins

Protein Information

Cellular senescence is the terminal non-dividing state that normal cells enter following completion of their proliferative potential. Fusions of immortal human cell lines with each other have led to their assignment to one of four complementation groups. Mortality factor 4 (MORF4) was identified as the lead member of a family of transcription factor-like proteins that reverses this immortal phenotype. Like other members in this family, MORF4 is localized to the nucleus and possesses transcription factor-like motifs such as helix-loop-helix and a leucine zipper motif that might allow it to form transcriptionally active homo- or heterodimers. MORF4 has been shown to bind to the transcription corepressors mSin3A and TLE, suggesting that together, these complexes may play a role in transcriptional repression of genes that lead to cellular senescence.

Synonyms

9130413I22Rik; AL022827; csrb; Eaf3; Esa1p-associated factor 3 homolog; FWP006; HSPC008; HSPC061; HsT17725; MEAF3; mKIAA4002; MNCb-1039; Mof4 family associated protein 1; Morf4 family associated protein 1; MORF4 family-associated protein 1; MORF4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORFRG15; mortality factor 4 like 1; mortality factor 4-like protein 1; Mrfap1; mrfap1 {ECO:0000312; MRG15; Pam14; Pgr1; PP368; Protein associated with MRG of 14 kDa; protein associated with MRG, 14 kDa; protein MSL3-1; RGD:628631}; RGD1306635; S863-6; SEN1; T-cell activation protein; T-cell activation protein-related protein; TEG-189; testis expressed gene 189; testis-expressed gene 189 protein; Tex189; transcription factor-like protein MRG15