NALP10 Proteins

Protein Information

NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.

Synonyms

6430548I20Rik; CLR11.1; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; NALP10; Napl10; neuronal apoptosis inhibitor protein 10; NLR family pyrin domain containing 10; NLR family, pyrin domain containing 10; NLRP10; NOD8; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10; PAN5; Pynod