OVCA2 Proteins

Protein Information

Chromosome 17 is a hotspot for chromosomal aberrations in breast and ovarian cancer. Candidate oncogenes and tumor suppressors located on this chromosome include OVCA1 and OVCA2, p53, BRCA1, HER2/neu and others. OVCA1 and 2 map to a highly conserved region on human chromosome 17p13.3 that is deleted in 80% of ovarian cancers and shows frequent loss of heterozygosity in breast cancers. OVCA1 is induced by BRCA1 and is closely linked to p53, a well-known tumor suppressor gene. The close linkage of OVCA1 and p53 suggests that coordinated loss of the two genes may lead to ovarian, breast and other tumor types.

Synonyms

9030414M07Rik; candidate tumor suppressor in ovarian cancer 2; candidate tumor suppressor OVCA2; esterase OVCA2; hypothetical protein LOC534099; ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2; ovarian cancer gene-2 protein; ovarian cancer-associated gene 2 protein; Ovarian cancer-associated gene 2 protein homolog; ovarian tumor suppressor candidate 2; Ovca2; OVCA2 serine hydrolase domain containing; OVCA2, serine hydrolase domain containing; RGD1564623