PKN2 Proteins

Protein Information

PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

Synonyms

6030436C20Rik; AI507382; cardiolipin-activated protein kinase Pak2; p140 kinase; PAK2; Pak-2; PKN gamma; PKN2; PRK2; PRKCL2; PRO2042; protease-activated kinase 2; protein kinase C-like 2; protein kinase N2; protein-kinase C-related kinase 2; RP5-905H16.1; serine/threonine kinase 7; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2-like; si:ch211-83f14.1; Stk7; wu:fa97c07