PRPF39 Proteins

Protein Information

The PRPF39 gene plays a critical role as a splicing factor involved in alternative splicing regulation. In humans, it is homologous to the yeast Prp39 and Prp42 paralogs, forming a homodimer that interacts with the carboxy-terminal domain (CTD) of U1C, a parallel mechanism observed in the yeast Prp39/Prp42 heterodimer. Recent studies have highlighted its impact on splicing efficiency through knockdown experiments in HEK293 cells, which revealed significant changes in the expression of many genes, underscoring its importance in splicing adaptability according to cell type-specific needs. Additionally, PRPF39 is found to be highly expressed in Acute Lymphoblastic Leukemia (ALL), with research suggesting that targeting PRPF39 for degradation could contribute to the treatment of ALL. Phylogenetic analyses indicate a coevolution of PRPF39 expression with molecular components like shortened U1 snRNA, reflecting the splicing complexity across different species. The gene is also involved in the regulation of distant genes which are relevant to cellular responses, such as those involved in cisplatin response.

Synonyms

flj11128; flj20666; flj45460; mgc149842; mgc149843; pre-mRNA processing factor 39; pre-mRNA-processing factor 39; PRP39 homolog; PRP39 pre-mRNA processing factor 39 homolog; PRP39 pre-mRNA processing factor 39 homolog (yeast); PRPF39; Srcs1; v-src suppressed transcript 1