RBBP6 Proteins

Protein Information

This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

Synonyms

4933422O15Rik; AI316869; BB233631; C030034J04Rik; C77662; E3 ubiquitin-protein ligase RBBP6; im:7158869; MY038; my038-like; P2PR; P2P-R; p53-associated cellular protein of testis; PACT; Proliferation potential-related protein; protein P2P-R; RB binding protein 6, ubiquitin ligase; RB-binding Q-protein 1; Rbbp6; rbbp6l; RBQ1; RBQ-1; retinoblastoma binding protein 6; retinoblastoma-binding protein 6; retinoblastoma-binding protein 6, isoform 3; retinoblastoma-binding Q protein 1; RING-type E3 ubiquitin transferase RBBP6; SNAMA