RCAN2 Proteins

Protein Information

Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

Synonyms

calcineurin inhibitory protein ZAKI-4; Calcipressin-2; caskin-1-like; CSP2; Dcip2; Down syndrome candidate region 1-like 1; down syndrome candidate region 1-like protein 1; Down syndrome critical region gene 1-like 1; Down syndrome critical region gene 1-like 1 protein; Down syndrome critical region gene1-like 1; DSCR1L1; DSCR1L1 protein; LOW QUALITY PROTEIN: calcipressin-2; MCIP2; myocyte-enriched calcineurin interactin protein 2; myocyte-enriched calcineurin-interacting protein 2; Rcan2; RCN2; regulator of calcineurin 2; si:ch211-124g24.1; thyroid hormone-responsive (skin fibroblasts); thyroid hormone-responsive protein ZAKI-4; translation initiation factor IF-2; ZAKI4; ZAKI-4; zgc:85746