SI Proteins

Protein Information

This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.

Synonyms

2010204N08Rik; alpha-glucosidase; c-sis; fd42f04; fd44a09; Isomaltase; maltase-glucoamylase (alpha-glucosidase); maltase-glucoamylase, intestinal; mgam; oligosaccharide alpha-1,6-glucosidase; pdgf protein; PDGF subunit B; PDGF-2; Pdgfb; platelet derived growth factor, B polypeptide; platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor subunit B; Platelet-derived growth factor, same as Sis (Simian sarcoma viral oncogene homologue, c-sis); pro-sucrase-isomaltase (EC 3.2.1.48-10); SI; SIS; Si-s; SUCIMAL; Sucrase; sucrase isomaltase (alpha-glucosidase); sucrase isomaltase, structural; sucrase-isomaltase; sucrase-isomaltase (alpha-glucosidase); sucrase-isomaltase, intestinal; wu:fd42f04; wu:fd44a09