SNX2 Proteins

Protein Information

Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.

Synonyms

0610030A03Rik; CTB-36H16.2; hypothetical protein LOC509769; MGC5204; SNX2; sorting nexin 2; sorting nexin-2; Transformation-related gene 9 protein; TRG9; TRG-9