SON Proteins

Protein Information

The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq].

Synonyms

2900011L12Rik; AA409051; AU067731; BASS1; Bax antagonist selected in Saccharomyces 1; C21orf50; C81487; DBP5; DBP-5; HSPC310; HSPC312; KIAA1019; mKIAA1019; negative regulatory element-binding protein; NRE-binding protein; NREBP; Protein DBP-5; Protein SON; SON; Son cell proliferation protein; Son DNA binding protein; SON DNA-binding protein; SON3