TCF12 Proteins

Protein Information

TCF12, also known as HTF4, is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. TCF12 is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. TCF12, in combination with E2A, is required to block thymocyte proliferation prior to pre-TCR expression and is critical for proper T cell differentiation. Recent reports have shown that TCF12 is also a critical factor required for the development of invariant natural killer T cells.

Synonyms

A130037E08Rik; ALF1; bHLHb20; Class A helix-loop-helix transcription factor ME1; class B basic helix-loop-helix protein 20; CRS3; DNA-binding protein HTF4; E-box-binding protein; HEB; HEBAlt; helix-loop-helix transcription factor 4; HsT17266; HTF4; HTF-4; ME1; Meb; REB; Salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBPA; SCBP-alpha; TCF12; TCF-12; Transcription factor 12; transcription factor HTF-4