TNFR1 Proteins

TNFR1 Human recombinant proteins are validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most... TNFR1 Human recombinant proteins are validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. TNFR1... TNFR1 Human recombinant proteins are validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. TNFR1 Protein have been referenced in 8 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 5 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to... TNFR1 Human recombinant proteins are validated for use in the following applications: Bioactivity, Neutralization and Western blot control. These proteins are expressed in E. coli. Available Product Grades: Animal-Free and Research Use Only. Gibco and Invitrogen proteins are some of the most frequently published proteins. TNFR1 Protein have been referenced in 8 publications which can be found in our reference library. Our Gibco brand includes SKUs from PeproTech™, acquired by Thermo Fisher Scientific. Browse all 5 proteins, including biologically active options. Not finding the exact protein, grade or size needed? Contact us to discuss your specific application and product needs.

Protein Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

Synonyms

CD120a; CD120a antigen; FPF; hypothetical protein; metalloproteinase inhibitor 4; MGC19588; MS5; n-smase activation assoc. factor; p55; p55 TNF receptor; p55-R; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TBP1; TBPI; TIMP metallopeptidase inhibitor 4; Timp4; TIMP-4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4; TNF receptor alpha chain; TNF receptor superfamily member 1A; TNF-alphaR1; TNF-alpha-R1; TNFalpha-R1; TNFAR; TNFR; TNF-R; TNFR I; TNFR1; TNF-R1; Tnfr-1; TNFR1-d2; Tnfr-2; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRp55; Tnfrsf1a; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1

TNFR1 Proteins

Protein Information

Synonyms

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