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          • Home
          • › Search Tool
          • › Search Results
          • › Mm00445259_m1
          See other IL4 GE Assays ›
          Gene Symbol:
          Il4
          Gene Name:
          interleukin 4
          Gene Aliases:
          BSF-1, Il-4
          Chromosome Location:
          Chr.11: 53612460 - 53618665 on Build GRCm38
          Species:
          Mouse
          Species Specific ID (Flybase ID):
          -
          Assay ID Mm00445259_m1
          Best Coverage
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (19)

          Genomic Map

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          Assay Details

          Gene Symbol: Il4
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_021283.2 NP_067258.1 2 - 3 241 79
          GenBank mRNA AB174765.1 - 2 - 3 220 79
          AF352783.1 - 2 - 3 222 79
          BC027514.1 - 2 - 3 220 3376587 79
          M13238.1 - 2 - 3 237 79
          M25892.1 - 2 - 3 269 79
          X03532.1 - 2 - 3 243 79

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          More Information


          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Apoptosis Mammalian Gene Collection Recommended Assay Mus musculus Mouse Androgen Panel Mouse Chemokine Panel Mouse Immune Response Inventoried Mouse_Immune_Response Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Il4

          Panther Classification:

          Molecular Function -

          interleukin superfamily

          Gene Ontology Categories:

          Function(s) Process(es)

          microglial cell activation
          positive regulation of protein phosphorylation
          innate immune response in mucosa
          positive regulation of defense response to virus by host
          T-helper 1 cell lineage commitment
          positive regulation of immunoglobulin production
          negative regulation of acute inflammatory response
          negative regulation of chronic inflammatory response
          immune response
          cholesterol metabolic process
          positive regulation of cell proliferation
          regulation of proton transport
          negative regulation of epithelial cell migration
          positive regulation of B cell proliferation
          B cell costimulation
          positive regulation of interleukin-10 production
          positive regulation of interleukin-13 production
          T-helper 2 cell cytokine production
          positive regulation of T cell proliferation
          positive regulation of activated T cell proliferation
          B cell activation
          positive regulation of tyrosine phosphorylation of Stat5 protein
          defense response to protozoan
          negative regulation of macrophage activation
          positive regulation of mast cell degranulation
          negative regulation of nitric oxide biosynthetic process
          T-helper 2 cell differentiation
          positive regulation of chemokine biosynthetic process
          positive regulation of MHC class II biosynthetic process
          positive regulation of T cell differentiation
          negative regulation of osteoclast differentiation
          negative regulation of transcription, DNA-templated
          positive regulation of transcription, DNA-templated
          positive regulation of transcription from RNA polymerase II promoter
          positive regulation of isotype switching to IgE isotypes
          positive regulation of isotype switching to IgG isotypes
          regulation of inflammatory response
          positive regulation of peptidyl-tyrosine phosphorylation
          regulation of immune response
          negative regulation of T cell activation
          positive regulation of B cell activation
          positive regulation of sequence-specific DNA binding transcription factor activity
          positive regulation of mononuclear cell migration
          dendritic cell differentiation
          extrinsic apoptotic signaling pathway in absence of ligand
          positive regulation of myoblast fusion
          negative regulation of complement-dependent cytotoxicity
          negative regulation of T-helper 17 cell differentiation
          negative regulation of endothelial cell apoptotic process
          positive regulation of eosinophil chemotaxis
          negative regulation of extrinsic apoptotic signaling pathway
          cytokine activity
          cytokine receptor binding
          interleukin-4 receptor binding
          growth factor activity

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          Citations (19)

          TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis.
          Authors
          Liese J, Schleicher U, Bogdan C
          Journal
          Eur J Immunol - Page No 3424 (Sat Dec 01 00:00:00 UTC 2007)
          Volume (Year)
          37 (2007)
          Product Usage
          -
          Systemic PPARgamma ligation inhibits allergic immune response in the skin.
          Authors
          Dahten A, Koch C, Ernst D, Schnoller C, Hartmann S, Worm M
          Journal
          J Invest Dermatol - Page No 2211 (Mon Sep 01 00:00:00 UTC 2008)
          Volume (Year)
          128 (2008)
          Product Usage
          -
          Role of the C5a receptor (C5aR) in acute and chronic dextran sulfate-induced models of inflammatory bowel disease.
          Authors
          Johswich K, Martin M, Bleich A, Kracht M, Dittrich-Breiholz O, Gessner JE, Suerbaum S, Wende E, Rheinheimer C, Klos A
          Journal
          Inflamm Bowel Dis - Page No 1812 (Thu Aug 27 00:00:00 UTC 2009)
          Volume (Year)
          15 (2009)
          Product Usage
          -
          Echinostoma caproni (Trematoda): Differential in vivo cytokine responses in high and low compatible hosts.
          Authors
          Trelis M, Sotillo J, Monteagudo C, Fried B, Marcilla A, Esteban JG, Toledo R
          Journal
          Exp Parasitol - Page No (Thu Sep 16 00:00:00 UTC 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.
          Authors
          Rocha FJ, Schleicher U, Mattner J, Alber G, Bogdan C
          Journal
          Infect Immun - Page No 3823 (Wed Aug 01 00:00:00 UTC 2007)
          Volume (Year)
          75 (2007)
          Product Usage
          -
          Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
          Authors
          Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA
          Journal
          J Immunol - Page No 6133 (Tue Jun 01 00:00:00 UTC 2010)
          Volume (Year)
          184 (2010)
          Product Usage
          -
          Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization.
          Authors
          Sherry CL, Kim SS, Dilger RN, Bauer LL, Moon ML, Tapping RI, Fahey GC Jr, Tappenden KA, Freund GG
          Journal
          Brain Behav Immun - Page No 631 (Sat May 01 00:00:00 UTC 2010)
          Volume (Year)
          24 (2010)
          Product Usage
          -
          IL-21 administration into the nostril alleviates murine allergic rhinitis.
          Authors
          Hiromura Y, Kishida T, Nakano H, Hama T, Imanishi J, Hisa Y, Mazda O
          Journal
          J Immunol - Page No 7157 (Thu Nov 15 00:00:00 UTC 2007)
          Volume (Year)
          179 (2007)
          Product Usage
          -
          The effects of targeted deletion of cannabinoid receptors CB1 and CB2 on intranasal sensitization and challenge with adjuvant-free ovalbumin.
          Authors
          Kaplan BL, Lawver JE, Karmaus PW, Ngaotepprutaram T, Birmingham NP, Harkema JR, Kaminski NE
          Journal
          Toxicol Pathol - Page No 382 (Fri Jan 01 00:00:00 UTC 2010)
          Volume (Year)
          38 (2010)
          Product Usage
          -
          Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system.
          Authors
          Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N, Hoshino T, Fujimoto J, Nakanishi K
          Journal
          Int Immunol - Page No 791 (Sun Jun 01 00:00:00 UTC 2008)
          Volume (Year)
          20 (2008)
          Product Usage
          -
          The migration of T cells in response to influenza virus is altered in neonatal mice.
          Authors
          Lines JL, Hoskins S, Hollifield M, Cauley LS, Garvy BA
          Journal
          J Immunol - Page No 2980 (Wed Sep 01 00:00:00 UTC 2010)
          Volume (Year)
          185 (2010)
          Product Usage
          -
          Tumor necrosis factor-alpha: alternative role as an inhibitor of osteoclast formation in vitro.
          Authors
          Balga R, Wetterwald A, Portenier J, Dolder S, Mueller C, Hofstetter W
          Journal
          Bone - Page No 325 (Tue Aug 01 00:00:00 UTC 2006)
          Volume (Year)
          39 (2006)
          Product Usage
          -
          CD4(+)CD25 (+) Regulatory T Cells Suppress Th17-Responses in an Experimental Colitis Model.
          Authors
          Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R
          Journal
          Dig Dis Sci - Page No (Thu Jun 03 00:00:00 UTC 2010)
          Volume (Year)
           (2010)
          Product Usage
          -
          Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens.
          Authors
          Lech M, Kulkarni OP, Pfeiffer S, Savarese E, Krug A, Garlanda C, Mantovani A, Anders HJ
          Journal
          J Exp Med - Page No 1879 (Mon Aug 04 00:00:00 UTC 2008)
          Volume (Year)
          205 (2008)
          Product Usage
          -
          Administration of neural precursor cells ameliorates renal ischemia-reperfusion injury.
          Authors
          Wang PH, Schwindt TT, Barnabe GF, Motta FL, Semedo P, Beraldo FC, Mazzali M, Dos Reis MA, Teixeira Vde P, Pacheco-Silva A, Mello LE, Camara NO
          Journal
          Nephron Exp Nephrol - Page No e20 (Thu Jan 01 00:00:00 UTC 2009)
          Volume (Year)
          112 (2009)
          Product Usage
          -
          Topical omega-3 and omega-6 fatty acids for treatment of dry eye.
          Authors
          Rashid S, Jin Y, Ecoiffier T, Barabino S, Schaumberg DA, Dana MR
          Journal
          Arch Ophthalmol - Page No 219 (Fri Feb 01 00:00:00 UTC 2008)
          Volume (Year)
          126 (2008)
          Product Usage
          -
          The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins.
          Authors
          Veldhoen M, Hirota K, Westendorf AM, Buer J, Dumoutier L, Renauld JC, Stockinger B
          Journal
          Nature - Page No 106 (Thu May 01 00:00:00 UTC 2008)
          Volume (Year)
          453 (2008)
          Product Usage
          -
          Impact of systemic histamine deficiency on the crosstalk between mammary adenocarcinoma and T cells.
          Authors
          Hegyesi H, Colombo L, Pallinger E, Toth S, Boer K, Molnar V, Falus A
          Journal
          J Pharmacol Sci - Page No 66 (Sat Sep 01 00:00:00 UTC 2007)
          Volume (Year)
          105 (2007)
          Product Usage
          -
          Phthalate ester-induced thymic stromal lymphopoietin mediates allergic dermatitis in mice.
          Authors
          Shigeno T, Katakuse M, Fujita T, Mukoyama Y, Watanabe H
          Journal
          Immunology - Page No e849 (Tue Sep 01 00:00:00 UTC 2009)
          Volume (Year)
          128 (2009)
          Product Usage
          -

          Back To Top

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