Oncomine Childhood Cancer Research NGS Assay

Because childhood and young adult cancer are different

The types and driving genetic aberrations of these malignancies are different than those affecting the adult population, so a specifically designed, targeted but comprehensive panel is needed to advance clinical research and future precision oncology therapeutic solutions.

Oncomine Childhood Cancer Research Assay

The Ion Torrent Oncomine Childhood Cancer Research Assay is a next-generation sequencing (NGS) assay designed for comprehensive genomic profiling of childhood and rare cancer types including:

Childhood leukemias
Lymphomas
Sarcomas
Central nervous system and brain neoplasms

Comprehensive panel design with both a DNA and RNA component

Compiled by leading researchers and pediatric oncologists, the Oncomine Childhood Cancer Research Assay provides coverage of 203 unique genes, including thousands of fusion drivers that more commonly occur in childhood sarcomas and leukemias.

Comprehensive mutation coverage (86 genes)				CNV (28 genes)
ABL1	EGFR	IL7R	PDGFRA	ABL2	MDM4
ABL2	EP300	JAK1	PDGFRB	ALK	MET
ALK	ERBB2	JAK2	PIK3CA	BRAF	MYC
ACVR1	ERBB3	JAK3	PIK3R1	CCND1	MYCN
AKT1	ERBB4	KDM4C	PPM1D	CDK4	PDGFRA
ASXL1	ESR1	KDR	PTPN11	CDK6	PIK3CA
ASXL2	EZH2	KIT	RAF1	EGFR
BRAF	FASLG	KRAS	RET	ERBB2
CALR	FBXW7	MAP2K1	RHOA	ERBB3
CBL	FGFR1	MAP2K2	SETBP1	FGFR1
CCND1	FGFR2	MET	SETD2	FGFR2
CCND3	FGFR3	MPL	SH2B3	FGFR3
CCR5	FLT3	MSH6	SH2D1A	FGFR4
CDK4	GATA2	MTOR	SMO	GLI1
CIC	GNA11	MYC	STAT3	GLI2
CREBBP	GNAQ	MYCN	STAT5B	IGF1R
CRLF2	H3F3A	NCOR2	TERT	JAK1
CSF1R	HDAC9	NOTCH1	TPMT	JAK2
CSF3R	HIST1H3B	NPM1	USP7	JAK3
CTNNB1	HRAS	NRAS	ZMYM3	KIT
DAXX	IDH1	NT5C2		KRAS
DNMT3A	IDH2	PAX5		MDM2

Full exon coverage (44 genes)		Fusion and expression (97 genes)
APC	NF1	ABL1	GLI1	MYB	PLAG1	YAP1
ARID1A	NF2	ABL2	GLIS2	MYBL1	PTK7	ZMYND11
ARID1B	PHF6	ALK	HMGA2	MYH11	RAF1	ZNF384
ATRX	PRPS1	BCL11B	IL2RB	NCOA2	RANBP17
CDKN2A	PSMB5	BCOR	JAK2	NOTCH1	RARA	Gene expression
CDKN2B	PTCH1	BLC2	KAT6A	NOTCH2	RECK	BCL2
CEBPA	PTEN	BRAF	KAT6B	NOTCH4	RELA	BCL6
CHD7	RB1	CAMTA1	KMT2A	NPM1	RET	FGFR1
CRLF1	RUNX1	CCND1	KMT2B	NR4A3	ROS1	FGFR4
DDX3X	SMARCA4	CIC	KMT2C	NTRK1	RUNX1	IGF1R
DICER1	SMARCB1	CRLF2	KMT2D	NTRK2	SS18	MET
EBF1	SOCS2	CSF1R	LMO2	NTRK3	STAG2	MYCN
EED	SUFU	EGFR	LYN	NUP214	STAT6	MYC
FAS	SUZ12	ETV6	LZTR1	NUP98	TAL1	TOP2A
GATA1	TCF3	EWSR1	MAML2	NUTM1	TCF3
GATA3	TET2	FER	MAN2B1	NUTM2B	TFE3
GNA13	TP53	FGFR1	MECOM	PAX3	TP63
ID3	TSC1	FGFR2	MEFD2	PAX5	TSLP
IKZF1	TSC2	FGFR3	MET	PAX7	TSPAN4
KDM6A	WHSC1	FLT3	MKL1	PDGFB	UBTF
KMT2D	WT1	FOSB	MLLT10	PDGFRA	USP6
MYOD1	XIAP	FUS	MN1	PDGFRB	WHSC1

Optimized NGS workflow for fast results

The end-to-end workflow enables the analysis of a variety of sample types, including blood and bone marrow, fresh/frozen tissue, and FFPE tissue, in 2–3 days from sample to result. Up to eight samples can be multiplexed on a single Ion 540 Chip, allowing for flexibility in batch size.

It's NGS made easy with the Ion GeneStudio S5 System

The Ion GeneStudio S5 System is an advanced NGS system that leverages semiconductor technology to enable fast, accurate, and cost-effective genomic analysis, making it suitable for a wide range of applications, including targeted sequencing, gene expression profiling, and metagenomics.

Explore the Ion GeneStudio S5 System