One Lambda Devyser Accept cfDNA Assay

After a solid organ transplant, monitoring levels of dd-cfDNA can provide valuable insights into the organ's health and function*. The One Lambda Devyser™ Accept™ cfDNA single-tube NGS assay is a minimally invasive solution that helps provide precise and reliable results, to monitor cfDNA following kidney transplantation.


Assay key features and benefits

  • Dual donor distinction:  Can support accurately assigning the origin of detected cfDNA in patients with two kidney transplants
  • Highly sensitive: Enabling the detection of cfDNA at levels as low as 0.1%
  • Robust indel design: Utilizing 50 highly informative and population-independent indel markers, the assay detects and differentiates between two genetically distinct donors for each recipient
  • Unified workflow: Simplify your laboratory processes with a streamlined workflow for both screening and monitoring assays with as little as 45 minutes hands-on time
  • Straightforward data analysis: The user-friendly, dedicated software simplifies data analysis and bioinformatics, and the built-in quality controls facilitate confidence in results

What is the One Lambda Devyser Accept cfDNA Assay?

Minimally invasive and highly robust method for detecting dd-cfDNA

Accept cfDNA is an NGS assay designed to detect and analyze circulating dd-cfDNA in post-transplant human plasma samples. Its unique indel design allows for accurate results, reduces amplification and sequencing errors. Combined with an efficient workflow, Accept cfDNA is the ideal tool for post-transplant monitoring and provides early time to result when run in your own in house HLA lab.

 

On-demand webinar: A Minimally Invasive Test That Can Support Accurately Assigning the Origin of Detected cfDNA From Donors in Patients With Two Kidney Transplants


One Lambda Deveyser Accept cfDNA Assay is now IVDR certificated for dual donor testing

Dual donor testing using One Lambda Devyser Accept cfDNA can support accurately assigning the origin of detected cfDNA from donors in patients with two kidney transplants.

 

Current testing methods may inaccurately detect elevated levels of cfDNA from the non-functioning graft and can be falsely associated with the second graft in patients with two kidney transplants. These testing methods could be subjected to varying influence from the first graft creating additional complications in the post-transplant monitoring of graft function. The One Lambda Devyser Accept cfDNA test is highly sensitive and has been shown to reliably detect and differentiate cfDNA in patients with two kidney transplants.
 


How does the One Lambda Devyser Accept cfDNA Assay work?

Efficient workflow and reliable results for post-transplant monitoring

The One Lambda Devyser Accept cfDNA assay was developed in conjunction with a nephrologist to deliver efficiency and ease of use with minimal hands-on time. Labs can receive next-day results from sample to report allowing for timely results. Our dedicated software simplifies data analysis and bioinformatics capabilities, allowing for easy patient tracking in a single location. With the ability to import analyzed data into Histotrac, all information is consolidated, providing clear visibility of trends.

 

Fig. 1. Workflow.


Advanced molecular transplant monitoring solutions with the Devyser and Thermo Fisher Scientific collaboration


The collaboration between Devyser and Thermo Fisher Scientific combines expertise and resources to offer enhanced and cutting-edge molecular kidney transplant monitoring capabilities to transplant programs, HLA labs, and transplant clinicians. Backed by Thermo Fisher Scientific's robust commercial infrastructure, our collaboration helps support reliable, accurate, and high-quality testing solutions for healthcare providers worldwide.

 

Perform post-transplant monitoring with ease and condfidence using One Lambda Devyser Accept cfDNA


 

Product is CE-IVD marked but not 510(k)-cleared. Availability of product in each country depends on local regulatory marketing authorization status. © 2024 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified. Dvysr is a trademark of Devyser AB. Not all products are available in all countries. Please consult your local sales representative for details.