Resources | Thermo Fisher Scientific

Browse the following resources to learn how our portfolio of Thermo Scientific chromatography consumables can enhance and simplify your biopharmaceutical workflows.

Application notes

Protein biotherapeutics

Analytical workflow solutions to advance your protein biotherapeutics process development

Salt gradient analysis of monoclonal antibodies using a 3 μm monodisperse SCX chromatography column

Salt gradient analysis of Protein G using a 3 μm monodisperse SAX chromatography column

Accurate and precise quantification of mAb-released N-glycans with an amide HILIC column

High-throughput protein aggregate analysis of monoclonal antibodies using a novel dual-channel UHPLC instrument

An automated high-throughput workflow for peptide mapping to monitor post-translational modifications (PTMs) of monoclonal antibodies

A universal chromatography method for aggregate analysis of monoclonal antibodies

Automated biopharmaceutical protein digestion optimization for peptide mapping method development

Nucleic acid biotherapeutics

Analytical workflow solutions to advance your gene, mRNA, and oligonucleotide based in biotherapeutics process development

Separating different plasmid DNA forms on a pellicular anion exchange column

Separation of Large Double-Stranded DNA (dsDNA) Fragments Using a Wide-Pore Reversed-Phase Chromatography Column

Separation of Mixed-Base Oligonucleotides Using a High-Resolution, Reversed-Phase Chromatography Column

Ultra-High-Resolution Separation of Oligonucleotides on Pellicular Anion-Exchange UHPLC Columns

Identification and quantitation of oligonucleotides, impurities, and degradation products

Salt gradient separation and analysis of adeno-associated virus samples using a 3 μm monodisperse strong anion exchange chromatography column

Adeno-associated virus capsid protein characterization and host cell protein profiling using micro-flow UHPLC-Orbitrap MS

Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software

Characterization of mRNA 5’ capping products using an LC-HRAM-MS/MS analytical platform and Thermo Scientific BioPharma Finder software solution

Profiling raw material impurities of the lipid nanoparticle (LNP) components

Characterization of lipid nanoparticle (LNP) composition using UHPLC-CAD

Applying UHPLC-HRAM MS technology to characterize and quantify lipid components in vivo to support new LNP development

Webinars

Toward a Next-Generation Multi-Attribute Method (MAM): An Evaluation of the Orbitrap Exploris MX Mass Detector

The Orbitrap Exploris MX mass detector’s suitability as a next generation MAM instrument was evaluated and assessed by the Pfizer MAM team.

View webinar

Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.

The product is For General Lab Use Only - Not For Diagnostic Procedures. The application is For Research Use Only - Not For Use In Diagnostic Procedures.

The Thermo Scientific Orbitrap Exploris and Excedion series mass spectrometers are Orbitrap instruments with an atmospheric pressure ionization (API) source for liquid chromatography (LC) mass spectrometry (MS) high-throughput applications. The instruments are designed to be placed on a bench in the laboratory and maintain mass accuracy across chromatographic peaks, supporting confident identification and quantitation using high-resolution accurate-mass detection.