Welcome to susceptibility testing, empowered
Your newsletter is dedicated to exploring topics relating to antimicrobial susceptibility testing (AST), brought to you by our in-house experts. We look at everything from topics in the news, to emerging technology, pushing AST stewardship to the next level.
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susceptibility testing, empowered: Issue 6
Read articles from the latest issue below
Obtaining a definitive MIC result: Because you don’t know what you don’t know
Minimum inhibitory concentration (MIC) results can play an important role in fighting antimicrobial resistance (AMR) and in guiding optimal clinical decisions. It’s too important to fail, but there is still some uncertainty about the best way to generate results. So, when does true mean true, what is a “definitive” MIC, and how does it provide the best path to right-first-time decisions?
Antimicrobial spotlight: Lefamulin
Community-acquired bacterial pneumonia (CABP) is among the most common types of pneumonia with 5 million cases each year1, and is a leading cause of death by bacterial infection in the US.2 In recent years, the effectiveness of many antibiotics has declined due to growing antibiotic resistance. Learn more about one of the latest antimicrobials available on the Thermo Scientific™ Sensititre™ System in the U.S., lefamulin.
- National Ambulatory Medical Care Survey (NAMCS) and National Hospital Ambulatory Medical Care Survey (NHAMCS) 2009 - 2010. https://www.cdc.gov/nchs/data/ahcd/combined_tables/2009-2010_combined_web_table01.pdf (Last Accessed June 21, 2019).
- el Bcheraoui C, Mokdad AH, Dwyer-Lindgren L, et al. Trends and Patterns of Differences in Infectious Disease Mortality Among US Counties, 1980-2014. JAMA. 2018;319(12):1248–1260. doi:10.1001/jama.2018.2089
Tackling the COVID-driven increase in AMR starts in the laboratory
How did the coronavirus pandemic contribute to antimicrobial resistance? Our new SmartNote Post-viral syndrome: Tackling the COVID-driven increase in AMR starts in the laboratory looks at the data behind the facts.
Previous issues of susceptibility testing, empowered:
Highlights from the latest 2022 CLSI and EUCAST updates
University Hospital Southampton evaluates an automated broth microdilution platform vs. EUCAST disc diffusion
Curious about how a broth microdilution AST methodology would fit into your laboratory workflow? Explore how the University Hospital Southampton, UK, conducted a comparison study between the broth microdilution and disc diffusion methodologies and read about their experience with the Thermo Scientific™ Sensititre™ ARIS HiQ™ System for AST.
New Infection Management Coalition white paper: tackling AMR requires transformational change
Apply the learnings of COVID to AMR, says coalition.
Tackling the deadly spectre of antimicrobial resistance (AMR) requires urgent, transformational, whole-system change.
In a new whitepaper, The Infection Management Coalition (IMC) claims that now is the time for the healthcare ecosystem to unite against the “existential threat” of resistance.
Ensuring detection of novel antimicrobial resistant strains – look out for Carbapenemases
The development of antimicrobial resistance is part of natural evolutionary process among microorganisms, delivering beneficial traits in bacteria that protect the cell from the effects of specific antibiotics, thus conferring a survival advantage. However, the increased use, and misuse, of antimicrobials promotes the accelerated spread of resistance mechanisms, leading to the development of multi and pan-resistant bacteria that are untreatable with the antibiotics currently in use. The detection, correct diagnosis and treatment and surveillance of antimicrobial resistant organisms is key to fighting this growing global issue.
Balancing the dangers of sepsis and antimicrobial resistance
In recent years, awareness campaigns and policy decisions have contributed to a “better safe than sorry” approach to treating sepsis. However, such models mean patients may receive unnecessary antibiotics – a trend that can act as a contributing factor to the development of antimicrobial resistance (AMR).
The Future of AST: Towards faster results and quicker clinical decisions
Traditional methods of AST, which can define pathogens and guide right first-time treatment plans, can take up to 72 hours due to the requirement for overnight cultures. But new ways of doing things are emerging, and microbiologists are leading the charge.
Antibiotic susceptibility testing’s vital role in COVID-era antimicrobial stewardship
Antibiotic use changed considerably during the first wave of SARS-CoV-2 as the pandemic changed processes and priorities almost overnight. We won’t know the true impact of this shift on antimicrobial resistance (AMR) for some time. But as the medical science community adapts to the ongoing threat of SARS-CoV-2, we need robust stewardship programmes that take account of these changing pathways and utilize all the tools at our disposal.
Verification of new AST testing systems
Ready to implement a new antimicrobial susceptibility testing system into your laboratory? Even with a readymade solution, laboratories are often required to verify the performance of a new method in their own laboratory environment. Learn more about verification recommendations.
Innovation in antimicrobial development
We all understand the importance of AST and MIC surveillance in the global AMR stewardship effort. We are well versed in this arena, but with new antibiotic cefiderocol’s unique mode of action, we require a unique method of MIC – one that involves different testing conditions to those used for existing treatment options.
A Renaissance in Phage Therapy?
Hear from our first guest editor, Professor Martha Clokie, as we explore the novel potential treasure trove of bacteriophages, taking a look back at past uses as well as looking forward to alternative therapies of the future.
Discordant Antibiotic Use Can be Common, and Deadly
Empiric antibiotic therapy in suspected bloodstream infections is vital. Unfortunately, a new study shows that discordant use is both fairly common, and potentially lethal. Knowing what data from the microbiology laboratory can help optimize the use of empiric therapy is essential to potentially saving lives.
Looking into the future of Antimicrobial Susceptibility Testing (AST)
View our webinar with renowned expert Dr. Rafael Canton, as he explores why rapid antimicrobial susceptibility testing is so important at a time when antibiotic resistance is growing into one of the biggest challenges the world faces today.
Explore the relationship between coronavirus, sepsis and the rise in antimicrobial resistance
As we continue to adapt and respond to coronavirus, we’re also mindful of its potential connection to other life-threatening conditions, such as sepsis and the impact on antimicrobial resistance. Since the World Health Organization declared coronavirus a global health emergency, there is now more scientific data available to link coronavirus to sepsis.
World Quality Day is coming. But what does it mean to AST?
It's World Quality Day, on November 12th, 2020. In order to celebrate a globally established event we’ve explored the connection between quality and antimicrobial susceptibility testing from the perspective of our business, as a manufacturer, and the products you use as a healthcare provider.
Support your immunocompromised patients
Three new Research Use Only (RUO) Thermo Scientific™ Sensititre™ plates for Nontuberculous Mycobacteria (NTM), provide the most up-to-date recognized drugs available to treat clinically significant NTMs1. In particular, the introduction of a new Nocardia format supports adoption of the latest CLSI guidelines for management of the immunocompromised patient groups most affected by infections related to this organism. The addition of the antibiotic Clofazimine, also provides additional guidance and treatment options in multi-drug resistant isolates. Find out more about these products and The World Health Organizations’ focus to end the TB epidemic by 2030.
Increases in Ventilator Associated Pneumonias (VAP) due to coronavirus
The clinical microbiology team here at Thermo Fisher Scientific™ are in constant contact with healthcare workers dealing with coronavirus globally. Recently we received some important feedback which resulted in us supporting our customers implementing new testing workflows for coronavirus including adding Thermo Scientific™ Sensititre™ System testing options to support their laboratories increased demands for Candida albicans associated Ventilator Assisted Pneumonia (VAP). Visit the microbiology coronavirus support page.
New benchtop automated susceptibility testing system is now available in the U.S.
Did you know that 9 out of top 10 hospitals* use Thermo Scientific Sensititre AST System? The recent U.S. launch of the Thermo Scientific Sensititre ARIS HiQ System now better automates AST testing via Gold Standard-Level Minimum Inhibitory Concentration (MIC) accuracy**. The immediate accuracy of phenotypically-driven MIC values deliver reliable results that support reductions in routine re-tests (due to invalid AST results), additional confirmatory testing and the hidden costs associated with reporting delays, and inappropriate antibiotic usage.
Antimicrobials cefiderocol and imipenem/relebactam - now available
Updated Thermo Scientific Sensititre plates for multi-drug resistant Gram negative infections now include two new antimicrobials, cefiderocol and imipenem/relebactam. Cefiderocol and imipenem/relebactam, represent two of the latest treatment options approved by the FDA for complicated urinary tract infections (cUTIs), including pyelonephritis. Imipenem/relebactam is also indicated for the treatment of complicated intra-abdominal infections (cIAI) with a third label for hospital-acquired and ventilator-associated bacterial pneumonia (HABP and VABP respectively) expected in early June. Cefiderocol is the first approved antibiotic that functions as a siderophore, providing a unique method of penetrating the cell wall of Gram-negative bacteria, enabling its ability to overcome many of the resistance mechanisms that bacteria employ against antibiotics.
* US News and World Report 2019-2020 Best Hospitals Honor Roll
** Gram negative anaerobe susceptibility testing in clinical isolates using Sensititre and Etest methods. C. Hughes, C. Ashhurst-Smith, J.K.Ferguson. Pathology Volume 50, Issue 4, June 2018.
*** CLSI. Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes. 3rd ed. CLSI standard M24. Wayne, PA: Clinical and Laboratory Standards Institute; 2018.