To ensure product quality and consumer safety, pharmaceutical and biotechnology manufacturers must verify materials throughout production. The Thermo Scientific TruScan RM Handheld Analyzer uses lab-proven Raman spectroscopy to perform accurate and reliable material identification at the point of need, minimizing the need for costly and time-consuming laboratory sampling tests.
The analyzer’s non-destructive point-and-shoot sampling principle facilitates rapid verification of a broad range of chemical compounds through sealed packaging to minimize the risk of contamination and exposure.
Fast, efficient, reliable verification of different Opadry film coatings using TruScan RM Handheld Raman Analyzer with TruTools.
API quantification using TruScan RM Handheld Raman Analyzer with TruTools for finished product quality control.
The technology behind the TruScan Handheld Raman analyzers is Raman spectrometry, a type of vibrational spectroscopy that characterizes materials based on measured patterns of vibrational frequencies, or wavelengths. The analyzer emits a laser light at 785nm and detects scattered photons at other wavelengths. The scattered light is a unique fingerprint for that material, and the TruScan Handheld Raman analyzers uses this "spectral fingerprint" to identify raw material or finished drug products. The 785nm laser wavelength provides optimal balance for measuring most pharmaceutical materials without compromising spectral resolution or Raman signal intensity.
The TruScan Handheld Raman Analyzers analyzer’s patented multivariate residual analysis offers the most effective chemometric solution for material identification—with two spectral pre-processing options—that is easy to operate in challenging environments and sampling conditions.
The TruScan Handheld Raman Analyzers analyzer acquires the Raman spectrum of the material and, in real time, determines the uncertainty of that measurement, given factors such as the sample characteristics, instrument telemetry, environment and testing environment. Since the software models the uncertainty (or in statistical terms, standard deviation) directly, there is no calibration or user modeling involved with method development.
Learn more about our probabilistic approach for material verification and identification in this white paper.
Go beyond simple material ID and identify and quantify more materials—anywhere in the plant. With the Thermo Scientific TruTools chemometrics package embedded in the TruScan RM analyzer, users can build custom, advanced qualitative and quantitative models for complex materials analysis problems. Applications include, but are not limited to:
Handheld Raman spectrometers have fundamentally changed how the pharmaceutical industry performs incoming raw material identification testing. The TruScan RM Handheld Raman Analyzer continues to push the trend that it started with a new set of capabilities to improve quality testing initiatives for biopharmaceutical manufacturers.
A quality specialist from a Johnson & Johnson company will also share his experience with the use of Thermo Scientific TruTools for the quantification of APIs in their syrup products.
Breakthrough technologies and applications that are making pharmaceutical and biopharmaceutical processes more efficient.
Learn how the TruScan RM analyzer becomes a more powerful spectrometer with the TruTools chemometrics capability, which enables users to build custom models to be deployed on the analyzer for materials analysis at the point of need.