A disulphide-linked heterodimer, consisting of mb-1 (or CD79a) and B29 (or CD79b) polypeptides, is non-covalently associated with membrane-bound immunoglobulins on B cells to constitute the B cell Ag receptor. CD79a first appears at pre B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines.
B-cell antigen receptor complex-associated protein alpha chain; B-cell antigen receptor complex-associated protein alpha-chain; CD79a; CD79A antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; Ig alpha; Ig-alpha; IGA; immunoglobulin-associated alpha; MB-1; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
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