The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene.
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dCMP deaminase; dCMP deaminase antibody; DCTD antibody; Deoxycytidylate deaminase; deoxycytidylate deaminase antibody; MGC111062 antibody