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ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.
D11Moh34; Dot3; Eap30; EAP30 subunit of ELL complex; ELL-associated protein of 30 kDa; ESCRT-II complex subunit VPS22; hVps22; RGD1310144; si:dkey-220f10.1; snf8; SNF8 subunit of ESCRT-II; SNF8, ESCRT-II complex subunit; SNF8, ESCRT-II complex subunit, homolog; SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); vacuolar sorting snf8 ELL associated of 30kDa; vacuolar-sorting protein SNF8; VPS22; zgc:101578
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