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The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness.
6230410J09Rik; CMCS; DFNB82; G protein signaling modulator 2; G-protein signaling modulator 2; G-protein signaling modulator 2 (AGS3-like, C. elegans); G-protein signalling modulator 2 (AGS3-like, C. elegans); G-protein-signaling modulator 2; GPSM2; HGNC:29501; hypothetical protein MGC63574; LGN; LGN protein; Mosaic protein LGN; Pins; Pins homolog; pins homolog (Drosophia); Pinsa; RGD1560967; TPR-motif and GoLoco-motif containing protein; zgc:63574
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