Lactoferrin (LTF) is an 80kDa non-haem, iron-binding globular glycoprotein and member of the transferrin family present in milk and mucosal secretions, and also released from neutrophil granules during inflammation. LTF acts as a major first line defense against microbial infections, partly due to its ability to efficiently bind to and hence remove Fe3+ from the environment, but studies have also shown that LTF possesses bactericidal properties and proteolytic activity, capable of cleaving arginine-rich sequences within microbial proteins. Three isoforms of LTF have been identified: LTF-alpha, LTF-beta and LTF-gamma and receptors for LTF are expressed in the gastrointestinal tract, by macrophages, lymphocytes, neutrophils and platelets and also by some bacteria.
epididymis luminal protein 110; GIG12; Growth-inhibiting protein 12; HLF2; kaliocin-1; lactoferricin; Lactoferrin; lactoferroxin; Lactotransferrin; LF; neutrophil lactoferrin; Talalactoferrin
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