Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.
ORP-4; ORP4; OSBP-related protein 4; OSBPL1; OSBPL4; oxysterol binding protein-like 1; oxysterol binding protein-related protein 4; Oxysterol-binding protein 2; Oxysterol-binding protein-related protein 4