PARL Antibodies

Target Information

This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

D16Ertd607e; Mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; Parl; parl {ECO:0000250; Pbeta; P-beta; presenilin associated rhomboid like; presenilin associated, rhomboid-like; presenilin associated, rhomboid-like isoform 1 preproprotein; presenilin associated, rhomboid-like preproprotein; presenilins-associated rhomboid-like protein, mitochondrial; PRO2207; Psarl; PSARL1; PSENIP2; RHBDS1; rhomboid 7 homolog 1; UniProtKB:Q9H300}