This gene encodes a member of the glycosyltransferase O-Fuc family. This enzyme adds O-fucose through an O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cell surface and secreted proteins. O-fucose glycans are involved in ligand-induced receptor signaling. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
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FUT12; GDP-fucose protein O-fucosyltransferase 1; O-Fuc-T; o-fucosyltransferase protein; O-FucT-1; O-FUT; Peptide-O-fucosyltransferase 1