This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B