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This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease.
alpha glucosidase 2 alpha neutral subunit; alpha-glucosidase 2; AU042638; carbohydrate processing enzyme of the endoplasmic reticulum; G2an; GANAB; GIIA; glucosidase II alpha subunit; glucosidase II alpha-subunit; glucosidase II subunit alpha; glucosidase, alpha; neutral AB; GLUII; KIAA0088; mKIAA0088; neutral AB; neutral alpha-glucosidase AB
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