Antibodies that detect GCAP1 can be used in several scientific applications, including Western Blot, ELISA, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target GCAP1 in Human, Mouse, Rat, Non-human primate and Bovine samples. Our GCAP1 polyclonal and monoclonal antibodies are developed in Rabbit and Mouse. Find the GCAP1 antibody that fits your needs. Choose from 1 of 5 GCAP1 antibodies, which have been validated in experiments with 8 publications and 10 images featured in our data gallery.
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Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90% similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.
cone dystrophy 3; GCAP 1; Guanylate cyclase activator 1A; guanylate cyclase activator 1A (retina); guanylate cyclase-activating protein, photoreceptor 1; guanylin 1, retina; Guanylyl cyclase-activating protein 1
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